Exercise Triggers Stem Cells in Muscles

It has been discovered by the researchers that stem cells exist in the muscles of human being are responsive when a men or women exercises. Much of researches in this field has been conducted more researches can direct to new techniques of therapeutic nature by using these stem cells to recover the muscle injured previously and rehabilitate or prevent loss of muscle with age. Mesenchymal stem cells (MSCs) in very thin muscles are considered very significant for the repair of muscle in reaction to the injury of non-physiological nature, mainly in the response of injections which have chemical nature that considerably injure the tissue of muscle and cause inflammation. The researchers researched out that whether Mesenchymal stem cells (MSCs) also reacted to injury while exercising.

Because the exercise can cause some damage as part of the process of remodeling nature after the mechanical strain, it is strange if the accumulation of Mesenchymal stem cells (MSCs) was a response of natural type to exercise and whether these stem cells add to the valuable growth and rehabilitation process that emerge after the exercise.

The researchers also discovered that Mesenchymal stem cells (MSCs) in the muscles are greatly receptive and reactive to mechanical injury. They witnessed that the accumulation of Mesenchymal stem cells (MSCs) in the mice muscles after energetic and forceful exercise. Then, the researchers concluded that although Mesenchymal stem cells (MSCs) don't immediately help in making fibers for new muscle, they release factors of growth that encourage other stem cells in muscles to generate and fuse the fresh muscles, creating the cellular basis for healthy muscle health after the proper exercise.

The research has determined that stem cell in muscle of an adult may present the beginning for the health of muscle with the help of exercise and improved the muscle healing with movement/rehabilitation therapy. The reality that MSCs in the human being muscle have the power to discharge great concentrations of development factor into the system that is called circulatory through the exercise and also make us surprised if they present a complex relation among improved health for complete body and contribution in regular activity that is of physical nature.

Although it has been found that exercise is the greatest way for maintaining muscle as we get older, some people are even not adept to efficiently indulge in physical activity. In this way the disabilities can restrict the chances for the growth of muscle. The researchers are working with their full potential to know that how people can best use these stem cells efficiently and effectively to maintain the mass of muscle in the atrophy face.

Provided that the prompt increase in neurodegenerative diseases that are age-related, consisting dementia, it is of much significant to determine strategies to prevent, slow, even reverse such cognitive decline which is age-related. Even though, it is well-recognized that ordinary aging association reduces in cognitive and neurogenesis function, little is presently known concerning the influences of aging on the neural precursor endogenous cell population.  

Further, it has been provided that the stem cells in other parts of the body are recognized to turn into a compromise with older age people because they are powerless to replace damaged or lost cells effectively, researchers wanted to identify whether this was also the condition for those stem cells that are neural in nature and whether reversing or slowing the decline system would result in enhanced function. The researches that have been conducted in the past have shown that physical exercise encourages the neuron-genesis in the hippocampus in both aged and young mice, and can slow that memory loss which is age-related.

Depending on these results the researchers are still wanted to identify that whether physical exercise can reverse or slow the decline which age-related in the stem cells that are neural and are in charge for the production of new cell.  In addition to this, researchers are exploring the possible mechanisms that are responsible for the physical exercise and based on the endogenous neural stem cells activation and came to know those hormones which are related to the growth may be closely concerned in the process of activation.  

 Only at present, the neuroscientists understand that the brain protects a pool of neural stem cells, even into adult people, waiting to be hired to establish new connections. This is a significant portion of neural learning and plasticity. At present it has been known that the stem cells are there, researches are in process to conclude maximum things, even involving regulations related to them. Possibly they participate a role in particular diseases, like Alzheimers. Or possibly they could be oppressed to prevent or treat such diseases.

In conclusion, this a core step in gaining knowledge about the neural stem cells, but it is just the start for the long term understanding to hopefully understand the environmental and genetic factors that effect the function of neural stem cell. It is usually complex to extrapolate from this type of basic science to the applications of clinical nature – people never understand what type of applications will emerge.

Works Cited

Thomas M., et.al. (2003). "Myostatin negatively regulates satellite cell activation and self-renewal." Journal of Cell Biol 162 (6): 1135–47.

Sampaolesi M., et al. (2006). "Mesoangioblast stem cells ameliorate muscle function in dystrophic dogs". Nature 444 (7211): 545–9.

"Stem-cell therapy: Promise and reality." Consumer Reports on Health 17.6 (2007): 9–10. Academic Search Premier. EBSCO. Web. 12 Feb. 2012.